Description

PEG(AceticAcid)2(PEGdi-aceticacidorPEGdicarboxyl)withsuperiorqualityspecificationof ≥95%Substitution.

PEG(AceticAcid)2fromJenKemTechnologyisahomobifunctionalPEGemployedforaminepegylationandcrosslinking,reactivetowardstheaminegroupoflysine(s).HomobifunctionalPEGderivativesfrom JenKemTechnologyhavenumerousapplicationsascrosslinkersforPEGylationofproteinsandpeptides,nanoparticleandsurfacemodifications.ConjugationwithhomobifunctionalPEGsensures anincreaseddrugloadcomparedtopegylationwith linearPEGs.JenKemTechnologyoffersAceticAcidPEGAceticAcidwithMW2,000Da(CM-PEG2000-CM),MW3,500Da(CM-PEG3500-CM),MW5,000Da(CM-PEG5000-CM),andMW7,500Da(CM-PEG7500-CM),in1gand5gpackingsizes.

DifferentMWof PEG(AceticAcid)2maybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs. JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactusforbulkpricing.

Note:StartingJuly2016, PEG(AceticAcid)2isthenewnameoftheproductCarboxylPEGCarboxyl(MW2000Da(COOH-PEG2000-COOH),MW3500Da(COOH-PEG3500-COOH),MW5,000Da(COOH-PEG5000-COOH),andMW7500Da(COOH-PEG7500-COOH);orPEGDicarboxyl.JenKemTechnologyhasrevisedthenameoftheproducttobetterreflectthechemical structure,asmanyotherPEGderivativeswithCOOHgroup areofferedinthecatalog.

References:

1. Ji,F.,etal.,ADualpH/MagneticResponsiveNanocarrierBasedonPEGylatedFe3O4NanoparticlesforDoxorubicinDelivery,JournalofNanoscienceandNanotechnology,2018,18.7:4464-4470.

2.Xiao,S.,etal.,Aptamer-mediatedgenetherapyenhancedantitumoractivityagainsthumanhepatocellularcarcinomainvitroandinvivo,JournalofControlledRelease,2017.

3.Jing,P.,etal,Enhancedgrowthinhibitionofprostatecancerinvitroandinvivobyarecombinantadenovirus-mediateddual-aptamermodifieddrugdeliverysystem,CancerLetters,2016,V.383(2),P.230-242.

4.Lorenzo,M.M.,etal., HomodimericProtein–PolymerConjugatesviatheTetrazine–trans-CycloocteneLigation,Macromolecules,2015.

5. Xue,Y.,etal., Quantifyingthiol–goldinteractionstowardstheefficientstrengthcontrol,Naturecommunications,2014,5.

6.Xu,P.,etal.,Hydrogen-bondedandreduction-responsivemicellesloADIngatorvastatinfortherapyofbreastcancermetastasis.Biomaterials,2014,35(26):p.7574-7587.

7.Gajbhiye,V.,etal.,Drug-loadednanoparticlesinducegeneexpressioninhumanpluripotentstemcellderivatives.Nanoscale,2014,6(1):p.521-31.

8.Gao,X.,etal.,Prostatestemcellantigen-targetednanoparticleswithdualfunctionalproperties:invivoimagingandcancerchemotherapy.IntJNanomedicine,2012,7:p.4037-51.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.