Description
PEG(SuccinimidylCarboxymethylEster)2withsuperiorqualityspecificationof ≥95%Substitution.
JenKemTechnology’sPEG(SuccinimidylCarboxymethylEster)2 (SCM-PEG-SCM,NHSPEGNHS,PEGdiNHS,orPEGdiSCM)isahighqualityaminereactivehomofunctionalPEGproductwithastablenon-degradablelinkerbetweenthePEGpolymericchainandtheNHSester.The SuccinimidylCarboxymethylEstergroupreactswiththeaminegroupoflysine(s)atroomtemperatureatpH7-8. JenKemTechnology’shomobifunctionalPEGderivativeshavenumerousapplicationsascrosslinkers,includingforPEGylationofproteinsandpeptides,nanoparticleandsurfacemodifications.ConjugationwithhomobifunctionalPEGsprovides anincreaseddrugloadcomparedtopegylationusinglinearPEGs.
JenKemTechnologyoffersPEGdiSCMEster withMW2kDa (SCM-PEG2000-SCM),MW3.5kDa(SCM-PEG3500-SCM),MW5kDa(SCM-PEG5000-SCM),MW7.5kDa(SCM-PEG7500-SCM),in1gand5gpackingsizes. DifferentMWofPEGdiSCMhomobifunctionalproductsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.
BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactusforbulkpricing.
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References:
1.Inostroza-Brito,K.E.,etal.,Cross-linkingofaBiopolymer-PeptideCo-AssemblingSystem,ActaBiomaterialia,2017.
2.Walker,J.M.,etal., MagneticallyTriggeredRADIcal-GeneratingFe3O4NanoparticlesforBiopolymerRestructuring:ApplicationtotheExtracellularMatrix, Chem.Mater.,2015,27(24),pp8448–8456.
3.Zhou,J.,etal.,Invivoevaluationofmedicaldevice-associatedinflammationusingamacrophage-specificpositronemissiontomography(PET)imagingprobe.Bioorganic&MedicinalChemistryLetters,2013,23(7):p.2044-2047.
Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.
