Description
MethoxyPEGSuccinimidylSuccinamidewithsuperiorqualityspecificationof ≥95%Substitution.
JenKemTechnology’sMethoxyPEGSuccinimidylSuccinamide(MethoxyPEGSSA)isahighqualityaminereactivePEGproductwithastablenon-degradablelinkerbetweenthePEGpolymericchainandtheNHSester.MethoxyPEGSuccinimidylSuccinamide reactswiththeaminegroupoflysine(s)suchasontheactiveingredientsofAdagen®,Pegademase,orPEG-adenosinedeaminase,atpH7-8. MethoxyPEGSuccinimidylSuccinamidehasa longerhydrolysishalf-lifecomparedwithM-PEG-SCM.JenKemTechnologyoffersMethoxyPEGSSA withMW5000Da(M-SSA-5000),andMW20000Da(M-SSA-20K),in1gand10gpackingsizes.
DifferentMWofMethoxyPEGSSA productsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearJenKemNHSesterPEGsareavailable–ifinterestedpleaseselectstablelinkerNHSPEGs,carbonatelinkerstableNHSPEGs,or cleavablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.
BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactus forbulkpricing.
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References:
1. FahrländerE.,etal.,PEGylatedhumanserumalbumin(HSA)nanoparticles:preparation,characterizationandquantificationofthePEGylationextent,Nanotechnology,2015,26(14):145103.
2.Li,C.,etal., Real-TimeMonitoringSurfaceChemistry-DependentInVivoBehaviorsofProteinNanocagesviaEncapsulatinganNIR-IIAg2SQuantumDot, ACSNano,2015,9(12),12255-12263.
3.Hoffman,M.D.,etal., Degradablehydrogelsforspatiotemporalcontrolofmesenchymalstemcellslocalizedatdecellularizedboneallografts.ActaBiomaterialia,2014,10(8):p.3431-3441.
Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.
