Description
GalactosePEGSuccinimidylCarboxymethylEsterwithsuperiorqualityspecificationof ≥90%Substitution.
GalactosePEGSuccinimidylCarboxymethylEsterisaJenKemTechnologyhighqualityaminereactivePEGproductwithasuccinimidylcarboxymethylesterreactivegroupandatargetinggalactosegroup.GalactosePEG SCMreactswithaminogroupoflysine(s)atroomtemperatureinunder1hr,atpH7-8.ThepresenceofthegalactosemonosaccharideincreasessignificantlytheselectivityofthePEGylationreaction.
JenKemTechnologyoffersGalactosePEGSuccinimidylCarboxymethylEsterwithMW35000(GALA-SCM-35K),in1gand10gpackingsizes.DifferentMWofGalactosePEGSuccinimidylCarboxymethylEsterproductsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs. JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.
BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactusforbulkpricing.
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References:
1.He,H.,etal.,Developmentofmannosefunctionalizeddendrimericnanoparticlesfortargeteddeliverytomacrophages:useofthisplatformtomodulateatherosclerosis,TranslationalResearch,2018,193,P.13-30.
2.He,H.,etal.,Bolsteringcholesterylesterhydrolysisinliver:Ahepatocyte-targetinggenedeliverystrategyforpotentialalleviationofatherosclerosis,Biomaterials,2017,130:1-3.
3.Weaver,E.A.,etal., EffectsofShieldingAdenoviralVectorswithPolyethyleneGlycolonVector-SpecificandVaccine-MediatedImmuneResponses, HumanGeneTherapy,2008,19:1369–1382.
Note:StartingJuly2016,GalactosePEGSuccinimidylCarboxymethylEsteristhenewnameoftheproduct GalactosePEGNHSEster(MW35000(GALA-NHS-35K)).
Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationdirectlyfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.
