Description

MethoxyPEGSuccinimidylGlutaratewithsuperiorqualityspecificationof ≥95%Substitution.

MethoxyPEGSuccinimidylGlutarate (MethoxyPEGSG)isahighqualityaminereactivemethyletherNHSPEGproductfromJenKemTechnology.MethoxyPEGSGisadegradable PEGwithacleavableesterlinkerbetweenthePEGpolymericchainandtheNHSester.LinearNHSPEGswithaCleavableLinker(degradablePEGs)areespeciallyemployed incontrolledreleasedrugdevelopmentapplications.MethoxyPEGSuccinimidylGlutarate reactswiththeaminegroupoflysine(s)atpH7-8,whiletheesterlinkageiscleavedunderregularestercleavingreactionconditions. MethoxyPEGSuccinimidylGlutaratehasaslightlylongerhydrolysishalflifecomparedtoMethoxyPEGSuccinimidylSuccinate. JenKemTechnologyoffersMethoxyPEGSGwithMW5000Da(M-SG-5000)andMW20000Da(M-SG-20K),in1gand10gpackingsizes.

DifferentMWofMethoxyPEGSuccinimidylGlutarateproductsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearNHSestersareavailable–pleaseselectother cleavablelinkerNHSPEGs; or stablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactus forbulkpricing.

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References:

1.HutanuD,FrishbergMD,GuoL,DarieCC(2014)RecentApplicationsofPolyethyleneGlycols(PEGs)andPEGDerivatives.ModChemappl2:132.doi:10.4172/2329-6798.1000132.ReadaboutselectapplicationsofJenKem® PEGsinthemedicaldevice,drugdevelopment,anddiagnosticsareas,includingdrugdelivery,woundhealing,cellculturemodels,andtissueregeneration.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationdirectlyfromethyleneoxide,enablingfaciletraceABIlityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.