Description

MethoxyPEGSuccinimidylSuccinatewithsuperiorqualityspecificationof ≥95%Substitution.

JenKemTechnology’sMethoxyPEGSuccinimidylSuccinate (MethoxyPEGSS)isahighqualityaminereactiveNHSPEGproductwithdegradablecleavableesterlinkerbetweenthePEGpolymericchainandtheNHSester.LinearNHSPEGswithCleavableLinker(degradablePEGs)areespeciallyemployed incontrolledreleasedrugdevelopmentapplications.MethoxyPEGSuccinimidylSuccinate reactswiththeaminegroupoflysine(s),or aminessuchasontheactiveingredientsofAdagen®,Peg-ademase,orPEG-adenosinedeaminase,PEGaspargase,PEG-L-asparaginase, orrelatedbiosimilars,atpH7-8,whiletheesterlinkageiscleavedunderregularestercleavingreactionconditions.JenKemTechnologyoffersMethoxyPEGSS withMW5000Da(M-SS-5000)andMW20000Da(M-SS-20K),in1gand10gpackingsizes.

DifferentMWofMethoxyPEGSuccinimidylSuccinateproductsmaybeavailablebycustomsynthesis,pleaseemailus attech@jenkemusa.comfordetailsoncustomPEGs.OtherlinearNHSestersareavailable–pleaseselectother cleavablelinkerNHSPEGs; or stablelinkerNHSPEGs.JenKemTechnology providesrepackagingservicesforanadditionalfee,pleasecontactusifyourequireadifferentpackagesizethanourcatalogselection.

BulkPEGsandGMPgradePEGsaremade-to-order.Pleasecontactus forbulkpricing.

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References:

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2.Mastorakos,P.,etal.,Biodegradablebrain-penetratingDNAnanocomplexesandtheirusetotreatmalignantbraintumors,JournalofControlledRelease,2017,262,P.37-46.

3.Mastorakos,P.,etal., BiodegradableDNANanoparticlesthatProvideWidespreadGeneDeliveryintheBrain,Small,2015.

4. Jain,S.,etal.,Combinatorialbio-conjugationofgemcitABIneandcurcuminenablesdualdrugdeliverywithsynergisticanticancerefficacyandreducedtoxicity, RSCAdv.,2014,4,29193-29201.

5.Tesfay,M.Z.,etal.,PEGylationofvesicularstomatitisvirusextendsviruspersistenceinbloodcirculationofpassivelyimmunizedmice.JVirol,2013,87(7):p.3752-9.

6. Helgeson,L.A.,etal,MechanismofsynergisticactivationofArp2/3complexbycortactinandN-WASP, eLife,2013,2:e00884.

7. Depp,V.,etal.,Nativeprotein-initiatedATRP:AviableandpotentiallysuperioralternativetoPEGylationforstabilizingBIOLOGics,ActaBiomaterialia,5(2),2009,p: 560-569.

Foundedin2001byexpertsinPEGsynthesisandPEGylation,JenKemTechnologyspecializesexclusivelyinthedevelopmentandmanufacturingofhighqualitypolyethyleneglycol(PEG)productsandderivatives,andrelatedcustomsynthesisandPEGylationservices.JenKemTechnologyisISO9001andISO13485certified,andadherestoICHQ7AguidelinesforGMPmanufacture.TheproductionofJenKem®PEGsisback-integratedtoin-housepolymerizationfromethyleneoxide,enablingfaciletraceabilityforregulatedcustomers.JenKemTechnologycaterstothePEGylationneedsofthepharmaceutical,biotechnology,medicaldeviceanddiagnostics,andemergingchemicalspecialtymarkets,fromlaboratoryscalethroughlargecommercialscale.