Description

Monodisperse Propionic Acid PEG8 Propionic Acid reagent with superior quality specification of ≥ 95% Purity.

Monodisperse Propionic Acid PEG Propionic Acid from JenKem Technology (discrete diPA PEG8, PEG8 diPropanoic acid, or PEG8 dicarboxyl) is a single molecule homobifunctional PEGs employed for amine PEGylation. Monodisperse PEG diPropionic Acid is more stable than PEG-diSCM. JenKem Technology’s monodisperse discrete PEG diPropionic Acid products are produced via very reproducible chemical reactions and lack the polydispersity of traditional PEG polymers. JenKem’s monodisperse diPropionic Acid PEGs retain the polyethylene glycol’s good solubility in water, while offering to PEGylated drugs the same PEG benefits of reduced aggregation and immunogenicity, and increased hydrodynamic volume. Monodisperse homobifunctional PEG derivatives from JenKem Technology are high quality crosslinkers for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs provides an increased drug load compared to PEGylation using linear PEGs.

JenKem Technology offers monodisperse Propionic Acid PEG Propionic Acid with MW 514.6 Da (PA-PEG8-PA) and MW 690.8 Da (PA-PEG12-PA), in 1g and 5g packing sizes. DiPropionic Acid PEGs with different number of -CH2-CH2-O- units, such as Propionic Acid PEG4 Propionic Acid (PA-PEG4-PA), may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

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References:

1. Hutanu D, et al., (2014) Recent Applications of Polyethylene Glycols (PEGs) and PEG Derivatives. Mod Chem appl 2:132. doi: 10.4172/2329-6798.1000132. Read about select applications of JenKem® PEGs in the medical device, drug development, and diagnostics areas, including drug delivery, wound healing, cell culture models, and tissue regeneration.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.